Cannabis contains more than 113 different chemical compounds known as cannabinoids. Cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC) are two types of chemical compounds derived from cannabis. In recent years, interest in the possible health effects and benefits of cannabis has grown. Much of this interest has focused on these two cannabinoids.
Cannabidiol, commonly known as CBD, is the second most common chemical compound found in cannabis. In general, the incidence of these cases is low and, compared to other drugs used to treat these diseases, CBD has a better side effect profile. While CBD in certain forms is legal in most states, the details of the legality of any THC or CBD product may vary from state to state. The duration of treatment is another important factor, as data on adverse effects are much more limited after chronic administration of CBD.
Research is still needed on larger cohorts of patients with CBD, and it is necessary to evaluate the effects of CBD after prolonged exposure on genotoxicity and cytotoxicity, hormones and the immune system. Currently, there is great interest in the possible medical use of cannabidiol (CBD), a non-intoxicating cannabinoid. It's also important to remember that CBD and THC act on different areas of the brain, and researchers don't yet fully understand the effects of these cannabinoids, either alone or in combination with each other. The most important consideration is whether or not there is sufficient scientific data to show that CBD is effective in treating a patient's disease or condition.
This review does not focus on therapeutic indications, but rather on the possible adverse effects, toxicities and drug interactions that may accompany CBD treatments, and which should be taken into account before using CBD in an unauthorized way for physiopathological purposes, since it has not yet been demonstrated to respond effectively to CBD. The authors suggest that there is an inverted U-shaped dose-response curve for the effects of CBD on anxiety. To understand the side effects and potential benefits of these products, it's important to first understand the differences between CBD and THC. The greatest success of CBD treatment is the reduction of seizures in children with refractive epilepsy.
The field is changing rapidly, but efficacy testing is currently limited to CBD as an antiepileptic. The purpose of this review is to inform doctors, pharmacists, nurses, patients, public health authorities and policy makers about the adverse effects of CBD, toxicities and drug interactions that should be evaluated before prescribing CBD.
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