Are there any known drug interactions with using high doses of delta 8 thc products in combination with other drugs or supplements?

People use delta-8-THC for nausea and vomiting caused by drug treatment for cancer, glaucoma, sleep problems, and many other conditions, but it's not good. It is known that CBD interacts with the metabolizing enzymes of cytochrome P450 drugs, and this affects the co-administration of CBD with other drugs that are also inhibited or metabolized by these enzymes. Very low doses of delta 8-THC increase food consumption and alter neurotransmitter levels after weight loss. A few hours are usually sufficient and allow the body's CYP3A4 enzymes to be regulated between doses.

Now that delta-8-THC has become the center of attention, it is crucial to understand the risk of drug interactions between delta-8.The interaction of CBD with AEDs and antidepressants is a topic of interest to doctors because of the possibility of consuming them simultaneously. The DrugBank database project is supported by the Canadian Institutes for Health Research (CIHR), Alberta Innovates - Health Solutions and the Metabolomic Innovation Center (TMIC). Delta-8 is known to be much less potent, so it is believed to have an even lower potential for drug interactions. The objective of this study was to provide a detailed and complete list of drug interactions that is aligned with information from the cannabinoid manufacturer PI.

One study found that studies on the inhibition and induction of THC, CBD and CBN of the main human isoforms of CYP-450 generally reflect a low risk of clinically significant drug interactions with most uses, but it also noted that human trials are lacking and that more information is needed. Interestingly, cannabidiol attenuated the anticonvulsant activity of levetiracetam and this interaction is pharmacodynamic in nature because there were no changes in serum and brain concentrations of levetiracetam or CBD. Effect of repeated administration of 11-hydroxy-delta 8-tetrahydrocannabinol, an active metabolite of delta 8-tetrahydrocannabinol, on the enzymatic system that metabolizes liver microsomal drugs in mice. One of the biggest advantages of Delta-8-THC is that it's federally legal when made with legal hemp material, meaning you can buy it online and have it shipped directly to your door.

The consequence of the lack of information on drug interactions is insufficient knowledge of their possible adverse reactions when consumed together. If a possible drug interaction is identified, this does not necessarily translate into a contraindicated combination or a clinically significant interaction, but rather an opportunity to evaluate the dose of the concomitant cannabinoid or IP. Since dronabinol PI indicates that the enzymatic and inhibitory potential of dronabinol is not fully understood, it can be assumed that there are possible pharmacological interactions with CYP2C9 and CYP3A4 SUBSTRATES. However, in view of ongoing research, changes in government regulations, and the constant flow of information related to drug treatment and drug reactions, the reader is recommended to consult the package leaflet for each medication for any changes in indications and dosage, as well as for additional warnings and precautions.

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