Delta-8 products may also increase the risk of developing or worsening a mental health condition. Marijuana has been linked to depression, social anxiety, and even suicide. Although there is plenty of information on the effects of THC, the same cannot be said for delta-8.Delta-8 is one of more than 100 cannabinoids naturally produced by the cannabis plant, but it is not found in significant quantities in the cannabis plant. However, there is a danger of buying types of cannabis, such as the controversial THC delta-8, which is banned in many states.
It's important for consumers to know that delta-8 THC products have not been evaluated or approved by the FDA for safe use in any context. It is weaker than delta-9, but it still interacts with the same cannabinoid receptors, producing the effects that people like from cannabis, but supposedly without negative effects, such as paranoia. CBD is a CB1 antagonist, a negative allosteric modulator in CB2 and an agonist of the transient cationic potential of subfamily V receptors (TRPV) and serotonin 1A receptors (5-HT1A), which produces anxiolytic, antipsychotic, anticonvulsant, antioxidant, analgesic and immunomodulatory functions, some of which cushion the harmful effects of THC, such as psychosis24. Very low doses of delta 8-THC increases food consumption and alters neurotransmitter levels after weight loss. Exposures do not necessarily represent poisoning or overdose and the AAPCC cannot fully verify the accuracy of all reports.
Delta-8 is promoted as a milder version of regular THC, which allows users to feel relaxed and euphoric without panicking or paranoia. Therefore, THC delta 8, which acts as a CYP3A4 inhibitor, can cause certain drugs to accumulate in toxic concentrations in the body, which is the basis of the possible interaction. As a hemp-derived cannabinoid, THC delta 8 is classified as a non-toxic substance, helping people feel comfortable incorporating it into their lifestyles. Ultimately, the only way to know if you can safely take Delta 8 THC and a particular prescription drug is to talk to your doctor.
The natural amount of delta-8 THC in hemp is very low and additional chemicals are needed to convert other hemp cannabinoids, such as CBD, into delta-8 THC (i.e., the effect of repeated administration of 11-hydroxy-delta 8-tetrahydrocannabinol, an active metabolite of delta 8-tetrahydrocannabinol, in the enzymatic system that metabolizes liver microsomal drugs in mice). The FDA is also concerned that delta-8 THC products may expose consumers to much higher levels of the substance than those found naturally in raw hemp and cannabis extracts. The reason why so many people are concerned about the possible interaction between Delta 8 hemp products and certain prescription drugs is due to the relationship between the cannabinoid and a metabolite called CYP3A4.
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