While generally considered safe, CBD can cause drowsiness, lightheadedness, nausea, diarrhea, dry mouth and, in rare cases, liver damage. Taking CBD with other medications that have similar side effects may increase the risk of unwanted symptoms or toxicity. In other words, taking CBD at the same time as over-the-counter or prescription drugs and substances that cause drowsiness, such as opioids, benzodiazepines (such as Xanax or Ativan), antipsychotics, antidepressants, antihistamines (such as Benadryl), or alcohol, can cause increased sleepiness, fatigue, and possibly accidental falls and accidents while driving. Increased sedation and tiredness can also occur when using certain herbal supplements, such as kava, melatonin, and St.
Taking CBD with stimulants (such as Adderall) may cause a decrease in appetite, while taking it together with metformin, a diabetes medication, or certain medications for heartburn (such as Prilosec) may increase the risk of diarrhea. Research has found that both CBD and THC rely heavily on the CYP3A4 metabolic pathway for absorption and are known to inhibit the CYP3A4 enzyme. That means that they have the potential to react with any drug that uses the same metabolic pathway, which sadly is most prescription drugs. Grapefruit is known to inhibit the CYP3A4 enzyme, which means that it can delay or prevent the absorption of drugs that depend on that enzyme.
Another study suggests that CBD is effective in reducing the frequency and severity of seizures compared to baseline in adults and children with treatment resistant epilepsy. In addition, CBD is capable of inhibiting CYP2C19, CYP2D6 and CYP2C9, and can inhibit members of the CYP311,12 family, which causes possible pharmacological interactions with other drugs13,14. With the increasing use of CBD and its wide availability among the general public, it is important to examine and report on possible pharmacological interactions between CBD and other therapeutic agents, as well as on addictive substances such as alcohol and tobacco. A pharmacist is a great resource to help you learn about a possible interaction with a supplement, an herbal product (many of which have their own drug interactions), or an over-the-counter or prescription drug. Be sure to ask your doctor about possible drug interactions in Delta-8 and make sure that you are up to date with current research on THC.
Interestingly, cannabidiol attenuated the anticonvulsant activity of levetiracetam and this interaction is pharmacodynamic in nature because there were no changes in serum and brain concentrations of levetiracetam or CBD. It is known that CBD interacts with the metabolizing enzymes of cytochrome P450 drugs, and this affects the co-administration of CBD with other drugs that are also inhibited or metabolized by these enzymes. It has been shown that CBD inhibits the metabolism of heroin (diamorphine) and the hydrolysis of 6-monoacetylmorphine under in vitro conditions, which may have clinical relevance. Although more research is needed, marijuana can have serious interactions with drugs such as warfarin (an increase in the international ratio normalized and risk of bleeding); clobazam (increased risk of benzodiazepines) toxicity); central nervous system depressants and sympathomimetics (additive effects); and theophylline, clozapine and olanzapine (reduced effectiveness).
CBD is extensively metabolized by the CYP450 enzymes of the liver, in particular by the CYP3A4 and CYP2C1910 isoforms. The consequence of the lack of information on drug interactions is inadequate knowledge of their possible adverse reactions when consumed together. Although the effects of CBD on alcohol consumption are not well understood, it is known that CBD acts as a 5-HT1A receptor agonist and the results suggest that CBD may attenuate alcohol consumption and, potentially, protect against certain harmful effects of alcohol, such as liver and brain damage. The interaction of CBD with AEDs and antidepressants is a topic of interest to doctors because of the possibility of consuming both simultaneously.
Delta-8 is known to be much less potent, so it is believed to have an even lower potential for drug interactions. .
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